PREGNANCY-RELATED CONDITIONS
PLACENTA ACCRETA SPECTRUM
Placenta accreta spectrum is a condition in which the placenta abnormally attaches to the uterine wall (muscle) during the pregnancy. At the outset of a normal pregnancy, the placenta forms from cell division of the zygote (the initial fertilized eg). Part of these dividing cells nestle into the uterine lining covering the wall of the uterus and grow into the placenta, while the other part of the diving cells develop to become the embryo (and later fetus), which is connected to the placenta through the umbilical cord. The uterine lining (endometrium) is a mucosal layer of cells that is produced by the body specifically for the purpose of allowing the placenta to implant and grow drug pregnancy. If the endometrium does not grow properly, for instance because it was damaged due to previous uterine surgery such as a prior cesarean section or an endometrial ablation, the placenta will sometimes attached directly to the underlaying uterine wall instead. Therefore, placenta accreta is considered to be a spectrum, based on the degree of ingrowth of the placenta into the uterine muscle. If the placenta is merely attached to, but not necessarily grown into, the uterine wall, the condition is considered a classical placenta accreta. If the placenta has actually grown into the uterine wall, the condition is considered a placenta increta. If the placenta has grown through the uterine wall and invaded other structures and organs, such as the bladder, the condition is considered to be a placenta percreta. The prevalence of placenta accreta spectrum is relatively low, although it has risen considerably in recent years, likely due to the increased use of uterine surgeries and procedures since the 1970s and 1980s. Now, it is estimated that between 0.2 % and 0.4 % of pregnancies (2 to 4 out of 1,000) are affected by placenta accreta spectrum. Placenta accreta spectrum often does not present with any symptoms and can even remain undetected on ultrasound exams. If therefore, placenta accreta is not diagnosed prior to the delivery, it can cause serious complications during the delivery, including hemorrhages and birth injuries. This is why it is important to be aware of the potential risk factors discussed below and, if necessary, discuss careful monitoring and possible treatment approaches with your doctor.
Risk Factors
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​Advanced maternal age (> 35)
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Higher number of previous pregnancies
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Multi-gestational pregnancy (twins or multiplets)​
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Placenta previa during the current or a previous pregnancy
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Uterine scarring (from any type of previous uterine procedures, both traditional and minimally invasive, including C-sections)
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In-vitro fertilization (IVF), although this can be confounded with maternal age
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Smoking
Symptoms
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Pelvic pain and blood in urine (placenta percreta)
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Uterine bleeding (occasionally during third trimester)
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No symptoms at all - it is important to follow up with your routine ultrasounds and ask your doctor about the risk of placenta previa
Treatments
If placenta accreta spectrum is diagnosed prior to the delivery:
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Hysterectomy (in extreme cases, to stop uterine bleeding)
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Medical treatment with coagulative drugs such as tranexamic acid
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(Surgical) removal of the placenta from the uterine wall after delivery
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Careful monitoring in the hospital to allow the placenta to detach form the uterus over the days after delivery (although this comes with severe risks of infection and bleeding)
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Induced preterm vaginal birth possible in milder cases
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Scheduled cesarean section
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Blood transfusions
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Bed rest
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If placenta accreta spectrum is diagnosed during or after the delivery:
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Coagulative medications
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Maternal blood transfusions
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Surgical removal of placenta can be attempted
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Hysterectomy (in extreme cases, to stop uterine bleeding)
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Complications
Risks for the mother: ​​
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Infertility (if hysterectomy)
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Hemorrhage
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Shock
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Risks for the fetus:
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Birth defects
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Preterm delivery
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