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GYNECOLOGIC ONCOLOGY

OVARIAN CANCER

Ovarian cancer describes a type of cancer that develops from cells of the ovaries - the two almond-shaped structures that are responsible for ovulation (release of a monthly ovum) and secrete the female reproductive hormones estrogen and progesterone. Sometimes, cancers that develop from the fallopian tubes (the structures that take up the ovum and transport it to the uterus) are also counted in this category. There are different types of ovarian cancers. The most common type, which is thought to account for about 90 % or more of ovarian cancers, is epithelial ovarian carcinoma (which can be subdivided in four main subtypes, serous carcinoma, endometrioid carcinoma, clear cell carcinoma and mucinous carcinoma). It develops from the epithelial cells forming the outer lining of the ovaries. Because epithelial tumors often do not exhibit clear symptoms until they are progressed to a more advanced stage, they tend to remain undiagnosed and untreated for long periods of time, thereby leading to decreased remission and increased death rates. A second type of ovarian cancers are ovarian stromal tumors (if these tumors are cancerous, they are also called stromal cell ovarian cancer). They grow from the stromal cells, a connective tissue located at the inside of the ovary, which lends the ovary stability and support. Because these tumors grow at the inside of the ovary, they often significantly interfere with the function of the ovary - including hormone production - which can lead to irregular vaginal bleeding (overproduction of estrogen) or excessive growth of facial and body hair (overproduction of testosterone). Because of these marked symptoms, stromal tumors are often diagnosed earlier, making treatment and recovery more successful, and reducing death rates. A third - but very rare -  type of ovarian cancer are malignant germ cell tumors. These tumors grow from the female germ cell, the ovum, and can affect younger women. One common form of germ cell tumor, which can be benign or malignant, is the teratoma. Because teratomas grow from the pluripotent germ cells of the ovum, a histology of the tumor after it is resected will often show a variety of different tissue types, including hair, teeth, skin, blood vessels and even eye and brain-like structures. Depending on whether or not the germ cell was properly released by the ovary, these tumors can occur either in the ovary, the Fallopian tube, or the uterus. Despite their uncommon origin and appearance, germ cell tumors are usually successfully removed and treated. 

Not all ovarian tumors are clearly cancerous, however. In fact, these tumors operate on a continuous spectrum, with some being clearly benign, some being clearly malignant, and others having a less clearly definable intermediate molecular makeup. Moreover, ovarian masses can also be benign fluid-filled cysts, which often resolve on their own and do not require any treatment at all. 

Risk Factors

The causes of ovarian cancer are not well understood, although like most cancers, it is believed ​to have its origins in a combination of genetic and environmental conditions. Risk factors that can contribute to the occurrence of ovarian cancers include age, prior history of cancer (both personal and family), obesity, smoking, increased exposure to the hormones estrogen and progesterone (for instance due to to early onset of menarche, late onset of menopause, hormonal fertility treatments or being placed on hormone replacement therapy after menopause), lack of parity (pregnancy), and history of other disorders of the female reproductive system, especially endometriosis

Symptoms

Symptoms of ovarian cancer, though rather generic and therefore often difficult to identify, include back pain, abdominal pain and swelling, decreased appetite and weight loss, changes in bowel movements and urination (frequency and urgency) and general fatigue. It is important to identify and follow up on these symptoms as early as possible. Many ovarian cancers, especially epithelial ovarian cancers, are not diagnosed until they have progressed to an advanced stage, which is the reason for their relatively high mortality rate (30-40% if diagnosed late, as opposed to as much as 80-90% if diagnosed early).

Risk Factors
Symptoms

Diagnosis

If any or several of the above symptoms are persistent and become concerning, further workup might be advisable. Initially, this can include analysis of the medical history (prior diagnoses), a physical (pelvic) exam, and blood tests (which can be positive for certain protein markers found on cancer cells). Though such tests cannot confirm a diagnosis of ovarian cancer, if they are positive, they can be grounds for further inquiry, including imaging (Ultrasound, X-Ray, CT, MRI, and PET) and, most importantly, a biopsy (removal of a small tissue sample to determine its molecular properties and determine whether the cells are cancerous). Biopsy is the only way of arriving at a definitive diagnosis of ovarian cancer, and stage (analyze) the cancer, which is an important factor in treatment success.

Treatments

Treatments of ovarian cancer are similar to those of breast and other gynecological cancers. They include surgical resection of the cancer. If the size and type of the cancer allow, the tumor will be resected without removing the affected ovary and/or adjacent Fallopian tube. However, often - especially with more aggressive and advanced types of cancer that infiltrate close by structures - a removal of the ovary and/or Fallopian tube (either unilaterally or bilaterally) may be required (salpingo-oophorectomy). In rare cases, a complete removal of all reproductive organs (including the uterus) may be suggested - preventing further pregnancies and inducing menopause. If the cancer has already spread throughout the abdomen, parts of other organs, such as the omentum (fatty layer covering the peritoneal cavity), stomach, liver, colon, small intestine, or bladder (or really, any other organ in the peritoneal cavity) may also have to be removed. Radiation therapy (external or internal) is often used before surgery to shrink the tumors, or after surgery to prevent recurrence. In addition to surgery and radiation, either neoadjuvant (before surgery) or adjuvant (after surgery) chemotherapy is often necessary (unless there are specific reasons making chemotherapy inadvisable). Chemotherapy regimens depends on what type and stage of ovarian cancer is being treated, including the chemotherapy drug (chemical agent) given, the doses and timeframe, as well as whether the chemotherapy is systemic (IV) and/or intra-peritoneal (locally inside the abdomen). Moreover, hormone therapy (decreasing the effect of estrogen on ovarian cells by either reducing estrogen production or estrogen receptor reactivity) and immunotherapy (inducing certain changes in the surface proteins of cancers cells that allow the immune system to recognize and eliminate these cancer cells) can be effective additional (and in some cases alternative) treatments.

Diagnosis
Treatments
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